PT  - JOURNAL ARTICLE
AU  - Gardier, Robert W.
AU  - Abreu, Benedict E.
AU  - Richards, Alice B.
AU  - Herrlich, Herman C.
TI  - SPECIFIC BLOCKADE OF THE ADRENAL MEDULLA
DP  - 1960 Nov 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 340--345
VI  - 130
IP  - 3
4099  - http://jpet.aspetjournals.org/content/130/3/340.short
4100  - http://jpet.aspetjournals.org/content/130/3/340.full
SO  - J Pharmacol Exp Ther1960 Nov 01; 130
AB  - N,N-diisopropyl- N'-isoamyl-N'-diethylaminoethylurea (P-286) reverses the pressor response to acetyicholine in the atropinized dog. This reversal is due to selective blockade of the action of acetyicholine in the adrenal medulla. P-286 possesses a transient vasodepressor action per se, has weak ganglionic blocking action, and is not an adrenergic blocking agent.