RT Journal Article
SR Electronic
T1 SITES OF ACTION OF THE AUTONOMIC EFFECTS OF 1,4-DIPYRROLIDINO-2-BUTYNE, TREMORINE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 62
OP 70
VO 135
IS 1
A1 Friedman, Alexander H.
A1 Smith, Cedric M.
YR 1962
UL http://jpet.aspetjournals.org/content/135/1/62.abstract
AB The administration of Tremorine has been demonstrated to produce: marked secretion of saliva by the submaxillary gland of the dog, bradycardia, hypotension, blockade of the effects of vagus nerve stimulation on the heart, increase in contraction and tone of the bladder, and facilitation of transmission in the superior cervical ganglion; a marked transient mydriasis in mice; negative inotropic and chronotropic actions on the isolated rabbit heart; inhibition of erythrocyte and intestinal mucosal cholinesterase in concentrations 103 to 104 those of neostigmine; stimulation and/or blockade of transmission through the inferior mesenteric ganglion of the cat. Section of the preganglionic nerves to the submaxillary, cardiac vagal, and inferior mesenteric ganglia did not prevent the action of Tremorine, whereas the systemic administration of ganglionic blocking agents or atropine decreased or blocked its action. It is therefore concluded that the site of Tremorine's autonomic effects is largely peripheral at ganglia. The significance of the inhibition of true and pseudocholinesterases in the production of these autonomic effects was not definitively determined.