RT Journal Article
SR Electronic
T1 THE EFFECTS OF RESERPINE ON UPTAKE OF EPINEPHRINE IN BRAIN AND CERTAIN AREAS OUTSIDE THE BLOOD-BRAIN BARRIER
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 11
OP 16
VO 135
IS 1
A1 Wilson, Cedric W. M.
A1 Murray, Anne W.
A1 Titus, Elwood
YR 1962
UL http://jpet.aspetjournals.org/content/135/1/11.abstract
AB Intravenously administered epinephrine-H3 was taken up in the pineal body, area postrema, and intercolumnar tubercle of the cat in concentrations considerably in excess of those in parts of the brain lying within the blood-brain barrier. The level of epinephrine-H3 in isolated brain tissue and pituitary slices that had been incubated with small amounts of labeled amine in vitro was higher than in the surrounding medium. The mechanism for concentration of epinephrine by these tissues became saturated at higher external concentrations of amine and was inhibited in reserpinized cats. Administration of reserpine to cats greatly reduced the concentrations of epinephrine-H3 appearing in pituitary, liver and muscle after intravenous administration.