TY - JOUR T1 - EFFECT OF ABLATION OF THE CHEMORECEPTOR TRIGGER ZONE (CT ZONE) ON THE EMETIC RESPONSE TO INTRAVENTRICULAR INJECTION OF APOMORPHINE AND EMETINE IN THE DOG JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 329 LP - 331 VL - 134 IS - 3 AU - K. P. Bhargava AU - P. C. Gupta AU - Om Chandra Y1 - 1961/12/01 UR - http://jpet.aspetjournals.org/content/134/3/329.abstract N2 - Intraventricular administration of apomorphine hydrochloride (0.5 µg/kg) and of emetine hydrochloride (0.2 mg/kg) regularly evoked vomiting in dogs. Ablation of the medullary emetic chemoreceptor trigger zone (CT zone) rendered the dogs refractory to the emetic effect of these drugs injected intraventricularly. Ablation of the CT zone also prevented vomiting in response to intravenous emetine. The findings confirm the postulate of a direct action of apomorphine on the CT zone. They also suggest that emetine acts on the CT zone. ER -