PT  - JOURNAL ARTICLE
AU  - HORVATH, ANTONIO
AU  - ORREGO, FERNANDO
AU  - McKENNIS, HERBERT
TI  - FACTORS CONTROLLING THE METABOLISM OF γ-AMINOBUTYRIC ACID
DP  - 1961 Nov 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 222--226
VI  - 134
IP  - 2
4099  - http://jpet.aspetjournals.org/content/134/2/222.short
4100  - http://jpet.aspetjournals.org/content/134/2/222.full
SO  - J Pharmacol Exp Ther1961 Nov 01; 134
AB  - Following intraperitoneal injection to the rat, 90 to 95% of the administered radioactivity of γ-aminobutyric acid-1-C14 is eliminated as respiratory carbon dioxide during the subsequent 18-hour period. Urinary excretion of radioactivity during this period accounts for an additional 3 to 8% of the dose. Simultaneous administration of hydrazine, semicarbazide, or isonicotinic acid hydrazide depressed metabolism of γ-aminobutyric acid-1-C14 to carbon dioxide. Concomitant significant increase in urinary radioactivity was observed only in the case of hydrazine. Administration of L-thyroxine to the rat daily for a period of 7 days prior to administration of γ-aminobutyric acid resulted in a decreased metabolism of γ-aminobutyric acid to carbon dioxide. All of the foregoing compounds which inhibited conversion of γ-aminobutyric acid to carbon dioxide in vivo inhibited conversion of γ-aminobutyric acid to succinic semialdehyde by γ- aminobutyric-α-ketoglutaric transaminase activity of brain homogenates. © 1961, by The Williams & Wilkins Company