RT Journal Article
SR Electronic
T1 THE EFFECT OF QUINIDINE ON THE POTASSIUM BALANCE OF THE DOG HEART
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 84
OP 89
VO 133
IS 1
A1 T. E. Brown
A1 G. Grupp
A1 G. H. Acheson
YR 1961
UL http://jpet.aspetjournals.org/content/133/1/84.abstract
AB Quinidine (25 to 55 mg) administered to the heart-lung preparation of the dog changes the positive (gaining) potassium balance of the heart to a negative (losing) one. The magnitude of the loss is small: 0.5 mEq/kg wet heart weight in 2 hours. Elevation of heart rate (1.5 to 2 times) doubles the rate of loss. Dihydro-ouabain (250 to 530 µg) counteracts only partially the evidences of failure produced by quinidine, but enhances the potassium loss 3 to 4 times. Increase of heart rate in this situation again doubles the potassium loss.