PT  - JOURNAL ARTICLE
AU  - Bernard L. Mirkin
TI  - THE EFFECT OF SYNAPTIC BLOCKING AGENTS ON RESERPINE-INDUCED ALTERATIONS IN ADRENAL MEDULLARY AND URINARY CATECHOLAMINE LEVELS
DP  - 1961 Jul 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 34--40
VI  - 133
IP  - 1
4099  - http://jpet.aspetjournals.org/content/133/1/34.short
4100  - http://jpet.aspetjournals.org/content/133/1/34.full
SO  - J Pharmacol Exp Ther1961 Jul 01; 133
AB  - The effects of chronic reserpine administration on free catecholamine levels in the adrenal medulla and in urine have been investigated: Pretreatment with synaptic blocking agents such as LSD, phenoxybenzamine and meprobamate did not antagonize the amine depleting action of reserpine. Prior administration of hexamethonium antagonized the depleting action of reserpine on the adrenal medulla. It also blocked the increase in urinary catecholamines produced by reserpine. 5-Hydroxytryptamine produced a significant depression of medullary catecholamine levels only in the presence of an amine oxidase inhibitor. It is proposed that catecholamine depletion produced by reserpine results from a dual action upon the central nervous system and the peripheral effector unit.