PT  - JOURNAL ARTICLE
AU  - Harold V. Lindstrom
TI  - THE METABOLISM OF FD&C RED NO. 1. I. THE FATE OF 2,4-META-XYLIDINE IN RATS
DP  - 1961 Jun 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 306--310
VI  - 132
IP  - 3
4099  - http://jpet.aspetjournals.org/content/132/3/306.short
4100  - http://jpet.aspetjournals.org/content/132/3/306.full
SO  - J Pharmacol Exp Ther1961 Jun 01; 132
AB  - The metabolism of the 2,4-meta-xylidine segment of FD&C Red No. 1 in rats can be outlined as follows: The xylidine is excreted to a small extent unchanged and to some extent conjugated as sulfamate and acetanilide. In view of many reports on the harmful effects of certain amino-phenols in animals, the failure of 2,4-meta-xylidine to develop an amino-phenol might mean that it is a constituent of FD&C Red No. 1 which is of lesser danger. For the must part the xylidine is oxidized at the para-methyl group to form 3-methyl-4-aminobenzoic acid; this metabolite is excreted to a small extent unchanged and as the glycine conjugate, but for the most part as the acetanilide.