PT  - JOURNAL ARTICLE
AU  - William J. Waddell
AU  - Thomas C. Butler
TI  - METABOLIC DEMETHYLATION OF 1,3-DIMETHYL-5-ETHYL-5-PHENYL HYDANTOIN (DIMETHYLNIRVANOL)
DP  - 1961 Jun 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 291--294
VI  - 132
IP  - 3
4099  - http://jpet.aspetjournals.org/content/132/3/291.short
4100  - http://jpet.aspetjournals.org/content/132/3/291.full
SO  - J Pharmacol Exp Ther1961 Jun 01; 132
AB  - 1,3-Dimethyl-5-ethyl-5-phenyl hydantoin (dimethylnirvanol) is converted in large part to 5-ethyl-5-phenyl hydantoin (Nirvanol) by the dog. The Nirvanol so produced has been isolated from urine and determined analytically in plasma. In the Nirvanol isolated from urine there was a preponderance of the levorotatory isomer. Evidence is presented that the course of the double demethylation is an initial rapid removal of the methyl group in the 1-position followed by a much slower removal of the methyl group in the 3-position.