PT  - JOURNAL ARTICLE
AU  - Irving Shemano
AU  - Herbert Wendel
AU  - Samuel D. Ross
TI  - A PHARMACOLOGICAL COMPARISON OF PHENAZOCINE HYDROBROMIDE AND MORPHINE SULFATE AS NARCOTIC ANALGESICS
DP  - 1961 May 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 258--263
VI  - 132
IP  - 2
4099  - http://jpet.aspetjournals.org/content/132/2/258.short
4100  - http://jpet.aspetjournals.org/content/132/2/258.full
SO  - J Pharmacol Exp Ther1961 May 01; 132
AB  - The pharmacological actions of phenazocine, a new potent narcotic analgesic, have been shown to be qualitatively similar to those of morphine. Phenazocine, like morphine, produces analgesia, tolerance, respiratory depression, hypotension, bradycardia, colon spasm, excitation and mydriasis in cats, possesses antiemetic properties and its effects are antagonized by N-allylnormorphine. The results indicate, however, that phenazocine exhibits a greater separation than morphine between its analgesic activity on the one hand, and its cardiovascular-respiratory depressant effects in anesthetized dogs on the other. The separation of analgesic activity of phenazocine from undesirable effects was also demonstrated by phenazocine's lack of emetic effect in dogs. The results of this study indicate that phenazocine is a promising agent for the treatment of pain.