PT  - JOURNAL ARTICLE
AU  - H. B. Hucker
AU  - J. R. Gillette
AU  - B. B. Brodie
TI  - ENZYMATIC PATHWAY FOR THE FORMATION OF COTININE, A MAJOR METABOLITE OF NICOTINE IN RABBIT LIVER
DP  - 1960 May 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 94--100
VI  - 129
IP  - 1
4099  - http://jpet.aspetjournals.org/content/129/1/94.short
4100  - http://jpet.aspetjournals.org/content/129/1/94.full
SO  - J Pharmacol Exp Ther1960 May 01; 129
AB  - A main reaction of nicotine metabolism in rabbit appears to be hydroxylation in the alpha position of the pyrrolidine ring to form a hydroxynicotine. This oxidation occurs in liver microsomes and requires TPNH and O2; the product has the properties of a cyclized amino aldehyde. The hydroxynicotine then undergoes oxidation to cotinine, a reaction that may be catalyzed by an aldehyde oxidase.