RT Journal Article
SR Electronic
T1 PHARMACOLOGIC STUDIES OF A NEW ANTITUSSIVE, <em>ALPHA</em> (DIMETHYLAMINOETHYL)-<em>ORTHO</em>-CHLOROBENZHYDROL HYDROCHLORIDE (SL-501, BAYER B-186)
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 384
OP 391
VO 128
IS 4
A1 James Y. P. Chen
A1 Hugh F. Biller
A1 Edwin G. Montgomery, Jr.
YR 1960
UL http://jpet.aspetjournals.org/content/128/4/384.abstract
AB The relative antitussive efficacies of alpha (dimethylaminoethyl)-ortho-chlorobenzhydrol hydrochloride (SL-501, Bayer B-186), codeine, dihydrocodeinone and several currently used nonnarcotic antitussives have been appraised by a method in which experimental cough was induced by aerosolized N sulfuric acid in unanesthetized dogs. SL-501, a new nonnarcotic antitussive, shows a potent and long-acting cough-suppressing activity in dogs. It has a relatively slower onset of maximum action than the narcotics. SL-501 exhibits moderate local anesthetic effects and a mild antispasmodic action. It also causes some prolongation of sleeping time in pentobarbitalized mice. No analgesic, sedative-hypnotic, antihistaminic or antiemetic properties were demonstrated. Acute and chronic toxicity studies in animals indicate that SL-501 is relatively nontoxic, and has a high therapeutic ratio.