RT Journal Article
SR Electronic
T1 PHARMACOLOGICAL AND ACUTE TOXICOLOGICAL COMPARISONS OF TRIFLUPROMAZINE AND CHLORPROMAZINE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 55
OP 65
VO 127
IS 1
A1 Joseph J. Piala
A1 John P. High
A1 G. Lee Hassert, Jr.
A1 John C. Burke
A1 Bradford N. Craver
YR 1959
UL http://jpet.aspetjournals.org/content/127/1/55.abstract
AB Triflupromazine (TFP) and chlorpromazine (CPZ) exhibited comparable acute toxicities in mice, rats and dogs except following intravenous administration when CPZ was more toxic in mice and less toxic in dogs. In small animals and in in vitro studies measurements of general depressant activity as well as of synergism with or antagonism toward other drugs indicated similar qualitative and quantitative actions for these two phenothiazines. More highly differentiated procedures in rats, monkeys and dogs, however, evidenced the higher potency of TFP as a tranquilizing and antiemetic agent and indicated less likelihood of cardiovascular side actions.