RT Journal Article
SR Electronic
T1 A COMPARISON OF HYPNOTIC AND RESIDUAL PSYCHOLOGICAL EFFECTS OF SINGLE DOSES OF CHLORPROMAZINE AND SECOBARBITAL IN MAN
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 51
OP 54
VO 127
IS 1
A1 Kornetsky, Conan
A1 Vates, Thomas S.
A1 Kessler, Edith K.
YR 1959
UL http://jpet.aspetjournals.org/content/127/1/51.abstract
AB Two doses of chlorpromazine and of secobarbital as well as a placebo were each given on different nights to 18 normal subjects at 7: 00 P. M. From the time of drug administration until the next morning at 7:00 A. M. a record of sleep activity of the subjects was obtained every half hour. Between 9:00 and 10:00 A. M. (14 to 15 hours postmedication) subjects were tested on three brief performance tests. The results indicate that 100 and 200 mg of chlorpromazine and 200 mg of secobarbital produce a significant increase in sleep time in the 18 subjects. One hundred and 200 mg of chlorpromazine and 200 mg of secobarbital cause significant impairment in subjects’ performance on psychological tests the morning after time drugs are administered, 14 to 15 hours postmedication. This residual impairment supports time clinical impression of the presence of a " hangover" effect the morning after barbiturate medication, and also indicates time ability of chlorpromazine to cause " hangover."