TY - JOUR T1 - STUDIES ON <em>ACORUS CALAMUS</em> (IV): INVESTIGATIONS ON MECHANISM OF ACTION IN MICE JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 334 LP - 337 VL - 126 IS - 4 AU - P. C. Dandiya AU - H. Cullumbine AU - E. A. Sellers Y1 - 1959/08/01 UR - http://jpet.aspetjournals.org/content/126/4/334.abstract N2 - Pretreatment of mice with lysergic acid diethylamide partly prevents the hypnotic potentiating action of Acorns oil. In iproniazid-treated mice, Acorus oil causes a fair degree of stimulation instead of sedation, noticed in untreated mice. The hypnotic potentiating action of Acorus oil is not a result of its hypothermic action. Reserpine does not prolong pentobarbital sleeping time, if the body temperature is not allowed to fall. The hypothermic action of chlorpromazine is only partly responsible for its hypnotic potentiating action. ER -