RT Journal Article
SR Electronic
T1 BIOCHEMORPHOLOGY OF RENAL TUBULAR TRANSPORT: HIPPURIC ACID AND RELATED SUBSTANCES
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 296
OP 303
VO 126
IS 4
A1 P. K. Knoefel
A1 K. C. Huang
A1 Nancy Buren King
A1 Leslie Talbott
YR 1959
UL http://jpet.aspetjournals.org/content/126/4/296.abstract
AB Hippuric acid and 33 related substances have been studied in the dog for their manner of renal excretion and their influence on renal tubular transport of p-aminohippurate. Hippuric acid is excreted by the renal tubule and exhibits quantitative competition with p-aminohippurate. Of the related substances, tubular excretion occured only with those containing the carhoxyl and a benzamido or benzimido group. Substituation in the phenyl of the benzamido group may reduce the tubular excretion. Substances with a carboxyl and also a carbonyl-or-imino group but lacking a benzamido or -imido group did not undergo tubular excretion. The spatial separation of the carhoxyl and benzamido groups is not critical for transport until a certain distance is exceeded. Many of the substances found not to undergo tubular excretion had a depressant action on transport of p-aminohippurate.