TY - JOUR T1 - EFFECTS OF PROBENECID, SODIUM SALICYLATE, 2,4-DINITROPHENOL AND PYRAZINAMIDE ON RENAL SECRETION OF URIC ACID IN CHICKENS JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 291 LP - 295 VL - 126 IS - 4 AU - Bohdan R. Nechay AU - Laryssa Nechay Y1 - 1959/08/01 UR - http://jpet.aspetjournals.org/content/126/4/291.abstract N2 - Probenecid was found to diminish renal tubular secretion of uric acid and to raise markedly plasma urate concentrations in the chicken. Sodium salicylate and 2, 4-dinitrophenol inhibition were less effective, but also reduced uric acid excretion. The 2, 4-dinitrophenol effect suggests that the tubular transport of uric acid may be dependent on energy supplied by oxidative phosphorylation. Since probenecid and sodium salicylate have previously been shown to inhibit reabsorption of uric acid in mammals, it is possible that there is a common factor in the transport mechanism for reabsorption and secretion of this substance. Pyrazinamide was without effect on uric acid clearance in this species. ER -