TY - JOUR T1 - STUDIES OF THE RENAL TUBULAR TRANSPORT CHARACTERISTICS OF N1-METHYLNICOTINAMIDE AND TETRAALKYLAMMONIUM COMPOUNDS IN THE AVIAN KIDNEY JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 195 LP - 201 VL - 126 IS - 3 AU - R. E. Green AU - W. E. Ricker AU - W. L. Attwood AU - Y. S. Koh AU - Lawrence Peters Y1 - 1959/07/01 UR - http://jpet.aspetjournals.org/content/126/3/195.abstract N2 - The evidence presented indicates that N1 methylnicotinamide (NMN), tetramethylammonium, tetraethylammonium and tetrabutylammonium are excreted by the same renal tubular transport system in the chicken. A large number of tetraalkylammonium derivatives and a number of aliphatic amines are capable of inhibiting the tubular transport of NMN when infused simultaneously with NMN into the renal portal circulation of the chicken. The inhibitor potency of these compounds increased progressively as the length of the alkyl substituents on the nitrogen was increased. ER -