@article {Yu185, author = {T. F. Yu and J. J. Burns and Peter G. Dayton and Alexander B. Gutman and Bernard B. Brodie}, title = {A p-NITRO ANALOGUE OF PHENYLBUTAZONE POSSESSING POTENT ANTI-RHEUMATIC, SODIUM RETAINING AND URICOSURIC PROPERTIES}, volume = {126}, number = {3}, pages = {185--189}, year = {1959}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {Studies have been carried out in man with an analogue of phenylbutazone which has a nitro group in the para position of one of the benzene rings. The compound is completely metabolized and disappears with a half-life of about 1 day. p-Nitrophenylbutazone has pronounced uricosuric properties along with the potent antirheumatic and sodium-retaining effects of phenylbutazone, the first member of the phenylbutazone series to exhibit all three properties in marked degree. The significance of these results in terms of structure-activity relationships in the phenylbutazone series is discussed.}, issn = {0022-3565}, URL = {https://jpet.aspetjournals.org/content/126/3/185}, eprint = {https://jpet.aspetjournals.org/content/126/3/185.full.pdf}, journal = {Journal of Pharmacology and Experimental Therapeutics} }