TY - JOUR T1 - EFFECT OF A NEW DRUG, N-(2-ENDOBICYCLO-(2,2,1)-HEPTANE)-DIETHYL-AMINOACETAMIDE HYDROCHLORIDE (ERL-239), ON MEAN ARTERIAL BLOOD PRESSURE, CARDIAC OUTPUT, CORONARY BLOOD FLOW, CARDIAC OXYGEN CONSUMPTION, WORK AND EFFICIENCY JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 164 LP - 167 VL - 126 IS - 2 AU - René Wégria AU - J. Nakano AU - J. C. McGiff AU - Tatiana Muraviev AU - H. Zekert AU - M. R. Blumenthal Y1 - 1959/06/01 UR - http://jpet.aspetjournals.org/content/126/2/164.abstract N2 - In the anesthetized dog, N-(2-endobicyclo- (2,2,1)-heptane)-diethylaminoacetamide hydrochloride (ERL-239) administered intravenously resulted in an increase of coronary blood flow. This increase occurred with doses which left the arterial blood pressure unchanged, with doses which lowered the arterial blood pressure only slightly and with doses which lowered the arterial blood pressure markedly. Cardiac output and work remained unchanged or decreased, cardiac oxygen consumption increased except with very large doses of the drug and cardiac efficiency always decreased. ER -