%0 Journal Article %A Thomas N. Burbridge %A V. C. Sutherland %A Charles H. Hine %A Alexander Simon %T SOME ASPECTS OF THE METABOLISM OF ALCOHOL IN VITRO %D 1959 %J Journal of Pharmacology and Experimental Therapeutics %P 70-75 %V 126 %N 1 %X A study in vitro indicates that the concentration of alcohol does influence the rate of metabolism by brain and liver. The data indicate that the metabolic system in brain differs from that of liver. The uptake of alcohol by brain was studied in the presence of various substrates. Glucose supported greater uptake than any of the others investigated. Ethanol only slightly decreases acetaldehyde uptake by brain in the presence of glucose, while acetaldehyde decreases ethanol uptake in the presence of a variety of substrates. Human brain differs from rat brain in regard to the influence of various substrates on alcohol uptake in vitro. Human brain is similar to rat brain in that pyruvate or acetaldehyde decreases its uptake of alcohol. © 1959 by The Williams & Wilkins Co. %U https://jpet.aspetjournals.org/content/jpet/126/1/70.full.pdf