RT Journal Article
SR Electronic
T1 COMPARATIVE EFFECTS OF CHLOROTHIAZIDE AND MERSALYL (MERSALYL SODIUM AND THEOPHYLLINE) ON THE KIDNEY
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 303
OP 308
VO 125
IS 4
A1 William P. Blackmore
YR 1959
UL http://jpet.aspetjournals.org/content/125/4/303.abstract
AB Chlorothiazide and mersalyl (mersalyl sodium and theophylline) administered intravenously to trained unanesthetized dogs under the conditions described in this study demonstrated the following: Chlorothiazide has a more rapid onset of action than mersalyl. Chlorothiazide is an effective diuretic even in the presence of a significant decrease in glomerular filtration rate, indicating a direct tubular response. In moderately hydrated dogs, chlorothiazide produced no change in "free" water clearance and a moderate increase in osmolar clearance. Mersalvl increased "free" water clearance and greatly increased osmolar clearance. In dogs undergoing maximal water diuresis both diuretics produced a significant increase in osmolar clearance and no significant change in "free" water clearance. The possible reasons for the difference observed between moderately and maximally hydrated dogs are discussed.