TY - JOUR T1 - THE MECHANISM OF SEROTONIN AND CATECHOLAMINE UPTAKE BY PLATELETS JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 96 LP - 102 VL - 127 IS - 2 AU - F. Barbara Hughes AU - Bernard B. Brodie Y1 - 1959/10/01 UR - http://jpet.aspetjournals.org/content/127/2/96.abstract N2 - Attempts to demonstrate the existence of a serotonin complex in suspensions of lysed rabbit platelets have not been successful. However, kinetic studies of serotonin uptake by platelets of normal and reserpine-treated guinea pigs indicate that serotonin is taken up by active transfer. Reserpine appears to act by blocking the active transport. Norepinephrine and epinephrine, but not bufotenine, can also be taken up in platelets in vitro by a process which is blocked by reserpine. ER -