TY - JOUR T1 - METABOLISM OF NICOTINE IN THE HUMAN AND EXCRETION OF PYRIDINE COMPOUNDS BY SMOKERS JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 92 LP - 95 VL - 127 IS - 2 AU - Edward R. Bowman AU - Lennox B. Turnbull AU - Herbert McKennis, Jr. Y1 - 1959/10/01 UR - http://jpet.aspetjournals.org/content/127/2/92.abstract N2 - Following the smoking of tobacco or ingestion of nicotine the urine of human subjects contained cotinine which was identified as the picrate and dipicrate. Chromatograms of the urines suggest the presence of hydroxycotinine and desmethylcotinine and related Koenig positive components and lead to the conclusion that cotinine plays, in man as well as in the dog, an important role as intermediate in nicotine metabolism. ER -