PT  - JOURNAL ARTICLE
AU  - James L. Spratt
AU  - George T. Okita
TI  - PROTEIN BINDING OF RADIOACTIVE DIGITOXIN
DP  - 1958 Oct 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 109--114
VI  - 124
IP  - 2
4099  - http://jpet.aspetjournals.org/content/124/2/109.short
4100  - http://jpet.aspetjournals.org/content/124/2/109.full
SO  - J Pharmacol Exp Ther1958 Oct 01; 124
AB  - Using zone electrophoresis, digitoxin binding by serum albumin could not be demonstrated. Using salt precipitation and dialysis methods, results obtained in the radiotracer portion of the present study agree qualitatively but not quantitatively with those of previous workers who found that digitoxin binding by serum proteins is correlated with albumin content of protein fractions. When doses within the "therapeutic" range are used, 1 mg of rat serum protein will bind 0.01 µg of digitoxin.