RT Journal Article
SR Electronic
T1 ANTIARRHYTHMICS. QUINIDINE-LIKE ACTIVITY OF SOME ATARAXIC AGENTS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 53
OP 58
VO 124
IS 1
A1 Arora, R. B.
YR 1958
UL http://jpet.aspetjournals.org/content/124/1/53.abstract
AB Alseroxylon, reserpine and benactyzine possess significant quinidine-like activity in prolonging the refractory period of isolated rabbit atria as well as in abolishing experimentally induced atrial fibrillation and flutter in anesthetized dogs. Meprobamate is not efficacious in the atrial arrhythmias althuough it shares the propensity of quinidine to increase atrial refractoriness. It, however, equals quinidine in the suppression of ectopic activity produced by 2-stage coronary ligation in unanesthetized dogs. In this test procedure, henactyzine and alseroxylon are stronger than quinidine while reserpine is considerably weaker.