PT  - JOURNAL ARTICLE
AU  - Arora, R. B.
TI  - ANTIARRHYTHMICS. QUINIDINE-LIKE ACTIVITY OF SOME ATARAXIC AGENTS
DP  - 1958 Sep 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 53--58
VI  - 124
IP  - 1
4099  - http://jpet.aspetjournals.org/content/124/1/53.short
4100  - http://jpet.aspetjournals.org/content/124/1/53.full
SO  - J Pharmacol Exp Ther1958 Sep 01; 124
AB  - Alseroxylon, reserpine and benactyzine possess significant quinidine-like activity in prolonging the refractory period of isolated rabbit atria as well as in abolishing experimentally induced atrial fibrillation and flutter in anesthetized dogs. Meprobamate is not efficacious in the atrial arrhythmias althuough it shares the propensity of quinidine to increase atrial refractoriness. It, however, equals quinidine in the suppression of ectopic activity produced by 2-stage coronary ligation in unanesthetized dogs. In this test procedure, henactyzine and alseroxylon are stronger than quinidine while reserpine is considerably weaker.