RT Journal Article
SR Electronic
T1 CARBONIC ANHYDRASE INHIBITION. IX. AUGMENTATION OF THE RENAL EFFECT OF MERALLURIDE BY ACETAZOLAMIDE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 311
OP 315
VO 123
IS 4
A1 Maren, Thomas H.
YR 1958
UL http://jpet.aspetjournals.org/content/123/4/311.abstract
AB After administration of the carbonic anhydrase inhibitor, acetazolamide, at 0 time and at 12 hr., there is augmentation of the effect of a mercurial diuretic, meralluride, when given at 24 hr., in promoting renal excretion of Na+, C1- and H2O, This augmentation appears to be due to prior excretion of HCO3 following acetazolamide, and the ensuing metabolic acidosis which is probably reflected in acidosis of renal cells. This may occur in the presence of normal plasma Cl- concentration. When meralluride and acetazolamide are given at the same time, and depending on the time intervals studied, chloride excretion may be less than that following meralluride alone. It is suggested that this repression is due to metabolic alkalosis of renal cells during carbonic anhydrase inhibition, at the time that the mercurial is acting. For maximal chloruretic effects, it is inadvisable to give the two agents together. Of a number of sequences studued, the most effective for 48-hour net sodium and chloride removal is acetazolamide on day 1 and meraluride on day 2.