PT  - JOURNAL ARTICLE
AU  - Harris Busch
AU  - P. V. Nair
AU  - Michael Frank
AU  - William R. Martin
TI  - COMPARATIVE PHARMACOLOGICAL EFFECTS OF A NUMBER OF β-HALOGENATED PYRUVIC ACIDS
DP  - 1958 May 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 48--53
VI  - 123
IP  - 1
4099  - http://jpet.aspetjournals.org/content/123/1/48.short
4100  - http://jpet.aspetjournals.org/content/123/1/48.full
SO  - J Pharmacol Exp Ther1958 May 01; 123
AB  - The cholinomimetic and other pharmacological effects of a series of highly purified halopyruvic acids are described and discussed in terms of their inhibitory effects on cholinesterase and their inhibition of oxidations in homogenate systems. The intensity of effects produced by dihalopyruvic acids was greater than that produced by the monohalopyruvic acids. Of the halopyruvic acids studied, dibromopyruvic was the most potent compound in production of salivation, lacrimation and analgesia; in addition, it exhibited the most marked anticholinesterase activity. The toxicity of these compounds was related, in part, to their inhibition of oxidation of substrates of the citric acid cycle.