RT Journal Article
SR Electronic
T1 BIOCHEMORPHOLOGY OF RENAL TUBULAR TRANSPORT: HALOGENATED AMINO ACIDS AND DERIVATIVES
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 443
OP 448
VO 121
IS 4
A1 K. C. Huang
A1 P. K. Knoefel
YR 1957
UL http://jpet.aspetjournals.org/content/121/4/443.abstract
AB Eleven halogenated amino acids and derivatives have been studied for binding to plasma protein and renal tubular transport. Tubular secretion was found to occur with diiodotyrosine and its diacetyl, N-acetyl, and N-carboxymethyliminocarbonyl derivatives. Tubular reabsorption occurred with N-2-iodophenyl-α-alanine, N-2,4-diiodophenyl-β-alanine, N-carbethoxy-diiodotyrosine, N-benzoyl-diiodotyrosine, S-4-bromobenzyl-cysteine, and N-acetyl-S-4-bromobenzyl-cysteine. N-2,3,5-triiodobenzoyl-tyrosine was neither absorbed nor excreted. None of the compounds were of value for Roentgen visualization of the urinary system.