PT  - JOURNAL ARTICLE
AU  - K. C. Huang
AU  - P. K. Knoefel
TI  - BIOCHEMORPHOLOGY OF RENAL TUBULAR TRANSPORT: HALOGENATED AMINO ACIDS AND DERIVATIVES
DP  - 1957 Dec 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 443--448
VI  - 121
IP  - 4
4099  - http://jpet.aspetjournals.org/content/121/4/443.short
4100  - http://jpet.aspetjournals.org/content/121/4/443.full
SO  - J Pharmacol Exp Ther1957 Dec 01; 121
AB  - Eleven halogenated amino acids and derivatives have been studied for binding to plasma protein and renal tubular transport. Tubular secretion was found to occur with diiodotyrosine and its diacetyl, N-acetyl, and N-carboxymethyliminocarbonyl derivatives. Tubular reabsorption occurred with N-2-iodophenyl-α-alanine, N-2,4-diiodophenyl-β-alanine, N-carbethoxy-diiodotyrosine, N-benzoyl-diiodotyrosine, S-4-bromobenzyl-cysteine, and N-acetyl-S-4-bromobenzyl-cysteine. N-2,3,5-triiodobenzoyl-tyrosine was neither absorbed nor excreted. None of the compounds were of value for Roentgen visualization of the urinary system.