RT Journal Article
SR Electronic
T1 A COMPARISON OF THE EFFECTIVENESS OF ADRENERGIC BLOCKING DRUGS IN INHIBITING THE CARDIAC ACTIONS OF SYMPATHOMIMETIC AMINES
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 183
OP 190
VO 121
IS 2
A1 Cotten, Marion Dev.
A1 Moran, Neil C.
A1 Stopp, Phyllis E.
A1 Keller, John G.
YR 1957
UL http://jpet.aspetjournals.org/content/121/2/183.abstract
AB Five adrenergic blocking drugs, each representing a different chemical class, have been examined for their effectiveness in inhibiting the increases in cardiac contractile force produced by levarterenol, epinephrine and isoproterenol in dogs with intact circulatory systems. Phentolamine and Dibenzyline completely blocked the cardiac actions of the amines, whereas large doses of piperoxan and azapetine blocked the effects by 50 to 75 per cent. Hydergine, even in very large doses, produced only 15 to 30 per cent blockade. With each blocking drug, the dose required to inhibit the cardiac responses of the amines was larger than that required to reverse the pressor response toepinephrine. None of the blocking drugs had any demonstrable influence upon the increases in contractile force produced by ouabain.