PT  - JOURNAL ARTICLE
AU  - Frawley, John P.
AU  - Fuyat, Henry N.
AU  - Hagan, Ernest C.
AU  - Blake, Jane R.
AU  - Fitzhugh, O. Garth
TI  - MARKED POTENTIATION IN MAMMALIAN TOXICITY FROM SIMULTANEOUS ADMINISTRATION OF TWOANTICHOLINESTERASE COMPOUNDS
DP  - 1957 Sep 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 96--106
VI  - 121
IP  - 1
4099  - http://jpet.aspetjournals.org/content/121/1/96.short
4100  - http://jpet.aspetjournals.org/content/121/1/96.full
SO  - J Pharmacol Exp Ther1957 Sep 01; 121
AB  - Data are presented to show up to 50-fold potentiation in the acute toxicity of EPN and malathion if they are administered simultaneously to dogs. The potentiation is marked but less for the rat. The potentiation from acute doses to dogs is associated with a marked increase in erythrocyte cholinesterase inhibition. Subacute experiments reveal that feeding of diets containing both EPN and malathion to dogs produces minimum blood cholinesterase inhibition at levels ½ to [unknown] the level required for the individual compounds for similar effect. Subacute studies with rats reveal increased cholinesterase inhibition, but again to a lesser degree than with the dog.