RT Journal Article
SR Electronic
T1 EFFECTS OF CHLORPROMAZINE ON THE ACQUISITION AND EXTINCTION OF AN AVOIDANCE RESPONSE IN THE RAT
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 144
OP 148
VO 121
IS 1
A1 Robert Ader
A1 Daniel W. Clink
YR 1957
UL http://jpet.aspetjournals.org/content/121/1/144.abstract
AB The present study was designed to determine the effects of chlorpromazine on the acquisition and extinction of a conditioned avoidance response. On the basis of acquisition rates, chlorpromazine and placebo groups were divided into drug and control groups for purposes of extinction. It was found that: Animals under the influence of chlorpromazine are significantly inferior to controls in acquiring the avoidance response. Increasing the dosage of chlorpromazine increases the number of trials required to attain the acquisition criterion. Without regard for the conditions under which the response was acquired, chlorpromazine (1.5 mgm./kgm.) decreases resistance to extinction. Whereas there were no differences in comparable groups under the smaller dosage, 3.0 mgm./kgm. of chlorpromazine decreases the resistance to extinction of animals having acquired the response under placebo.