PT  - JOURNAL ARTICLE
AU  - Graham Chen
AU  - Charles R. Ensor
AU  - Barbara Bohner
TI  - THE DEPRESSANT ACTION OF ETHYL TRICHLORAMATE ON THE CENTRAL NERVOUS SYSTEM
DP  - 1957 Sep 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 136--143
VI  - 121
IP  - 1
4099  - http://jpet.aspetjournals.org/content/121/1/136.short
4100  - http://jpet.aspetjournals.org/content/121/1/136.full
SO  - J Pharmacol Exp Ther1957 Sep 01; 121
AB  - The depressant effect of ethyl trichloramate (HY-185) on the central nervous system has been investigated and compared with that of chloral hydrate and urethane in rats and mice. HY-185 is as effective as chloral hydrate in producing sedation, hypnosis and general anesthesia. In addition, it produces a greater relaxation of skeletal muscles. HY-185 was found to be more effective than chloral hydrate in suppressing the maximal tonic-extensor seizure response of mice to electrical, pentylenetetrazol, or strychnine stimulation. This difference in anticonvulsant effect is probably due to a greater internuncial neurone depressant activity, which may also account for the muscle relaxant property of HY-185. The combined anticonvulsant and depressant effect of chioral hydrate and urethane in molecular equivalent quantities was found to be less than that of HY-185. In contrast, the acute lethal toxicity of HY-185 is less than the combined lethal toxicities of chioral hydrate and urethane. This indicates that HY-185 produces depression of the central nervous system probably as an intact molecule.