PT  - JOURNAL ARTICLE
AU  - Domingo M. Aviado, Jr.
AU  - Carl F. Schmidt
AU  - Sage E. Rosen
TI  - EFFECTS OF SYMPATHOMIMETIC DRUGS ON PULMONARY CIRCULATION: WITH SPECIAL REFERENCE TO A NEW PULMONARY VASODILATOR
DP  - 1957 Aug 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 512--527
VI  - 120
IP  - 4
4099  - http://jpet.aspetjournals.org/content/120/4/512.short
4100  - http://jpet.aspetjournals.org/content/120/4/512.full
SO  - J Pharmacol Exp Ther1957 Aug 01; 120
AB  - The pulmonary circulatory effects of various sympathomimetic amines were compared in anesthetized dogs with open chests. Measurements of vascular resistance of the perfused lobe and of pulmonary venous outflow in vagotomized animals revealed nine patterns of action: 1) pulmonary vasoconstriction and increased blood flow by levarterenol, epinephrine, tuaminoheptane, epinine and tyramine; 2) vasoconstriction and variable effect on blood flow by metaraminol; 3) vasoconstriction and decreased blood flow by phenylephrine; 4) variable effect on lung vessels and increased blood flow by hydroxyamphetamine, pholedrine and synephnin; 5) variable effect on both lung vessels and blood flow by ephedrine, amphetamine, phenylpropanolamine, methylaminoheptane and naphazoline; 6) variable effect on lung vessels and decreased blood flow by methoxamine; 7) vasodilator and increased blood flow by isoproterenol, nylidrin and methamphetamine; 8) vasodilator and no effect on blood flow by mephentermine, phenylpropylmethylamine and cyclopentamine; and 9) vasodilator and decreased blood flow by compound 45-50 (β-hydroxyl-β(2,5-diethoxyphenyl) isopropylamine). The last compound is a pulmonary hypotensive but systemic hypertensive drug which suggests its suitability for the drug therapy of pulmonary hypertension and systemic hypotension accompanying heat injury to the lungs.