TY - JOUR T1 - THE TOXICOLOGY OF POTASSIUM AND SODIUM IODATES: ACUTE TOXICITY IN MICE JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 171 LP - 178 VL - 120 IS - 2 AU - Stewart H. Webster AU - Mary E. Rice AU - Benjamin Highman AU - W. F. Von Oettingen Y1 - 1957/06/01 UR - http://jpet.aspetjournals.org/content/120/2/171.abstract N2 - Single-dose, acute toxicity experiments, carried out with white Swiss mice, using potassium and sodium iodates and the corresponding iodides, led to the following conclusions: Administered in sufficient quantities, the iodates cause intoxication and death. In some instances, death is attributed to renal damage with retention of non-protein nitrogen. Hemolytic effects are evidenced by hemoglobinuria and, histologically, by hemoglobin casts and hemosiderin deposits in the kidneys. Fatty visceral changes, non-specific in nature, appear within 24 hours after ingestion of iodates or iodides. Similar changes occur in fasted animals. Oral administration of iodates, at levels of 140 to 500 mgm./kgm., often increase the pH of the gastric contents. This is frequently accompanie by degenerative changes in the parietal cells. The damage is transient, as evidenced by restoration to normal in histological appearance of the gastric mucosa and in the pH values after 24 hours. Intraperitoneal and intravenous injections of iodates have little effect on the gastric pH. The toxicity of potassium iodate varies greatly with the route of administration; the oral LD50 for mice fasted on sawdust overnight is six times that of the intraperitoneal LD50. Potassium iodate and sodium iodate have nearly identical oral toxicities and similar intraperitoneal toxicities; the oral toxicity of the potassium compound is nearly the same for heavy and light mice and for both sexes, and is not increased in weanling animals. Similarly, the relative toxicities of iodates and iodides depend on route of administration and on previous treatment of the mice. © 1957 by The Williams & Wilkins Co. ER -