PT  - JOURNAL ARTICLE
AU  - Richard A. McLean
AU  - James F. Kerwin
AU  - Edwin J. Fellows
TI  - REACTION RATE AND ORAL EFFECTIVENESS OF CERTAIN ADRENERGIC BLOCKING COMPOUNDS
DP  - 1957 Apr 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 566--571
VI  - 119
IP  - 4
4099  - http://jpet.aspetjournals.org/content/119/4/566.short
4100  - http://jpet.aspetjournals.org/content/119/4/566.full
SO  - J Pharmacol Exp Ther1957 Apr 01; 119
AB  - Six pairs of beta-bromo- and beta-chloroalkylamines have been compared from the standpoint of intravenous and oral adrenolytic activity and in vitro reaction rate with sodium thiosulfate. An inverse relationship between chemical reactivity and oral effectiveness was found in all cases. It appears that a slow reaction rate favors absorption of the unaltered beta-haloalkylamine after oral administration. It is concluded that this factor may, in part, explain the lack of a direct correlation between intravenous and oral potency which was observed in previous experiments on the beta-haloalkylamines.