RT Journal Article
SR Electronic
T1 A POTENT NEW URICOSURIC AGENT, THE SULFOXIDE METABOLITE OF THE PHENYLBUTAZONE ANALOGUE, G-25671
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 418
OP 426
VO 119
IS 3
A1 Burns, J. J.
A1 Yü, T. F.
A1 Ritterband, Arnold
A1 Perel, James M.
A1 Gutman, Alexander B.
A1 Brodie, Bernard B.
YR 1957
UL http://jpet.aspetjournals.org/content/119/3/418.abstract
AB A sulfoxide metabolite of G-25671, a thio analogue of phenylbutazone, has been isolated from the urine of human subjects receiving the drug. The sulfoxide has a potent uricosuric effect and may account for all the activity observed with the parent drug. The possible usefulness of the sulfoxide as a therapeutic agent in the treatment of chronic gouty arthritis is discussed.