RT Journal Article
SR Electronic
T1 THE RESPIRATORY ACTIVITY OF CERTAIN NEUROMUSCULAR BLOCKING COMPOUNDS: A DIRECT PERIPHERAL AND CENTRAL COMPARISON
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 329
OP 342
VO 119
IS 3
A1 Irwin, Richard L.
A1 Wells, Jay B.
YR 1957
UL http://jpet.aspetjournals.org/content/119/3/329.abstract
AB A vascularly isolated, neurally intact head preparation has been used to determine whether succinylcholine, decamethonium or d-tubocurarine affect breathing by an action on central mechanisms. Doses of these compounds which produce a prolonged apnea in an anesthetized animal do not influence breathing in the absence of a peripheral effect. Thus, the data obtained in this study does not agree with the concept that these neuromuscular blocking compounds depress respiration by an action on central structures.