PT  - JOURNAL ARTICLE
AU  - Irwin, Richard L.
AU  - Wells, Jay B.
TI  - THE RESPIRATORY ACTIVITY OF CERTAIN NEUROMUSCULAR BLOCKING COMPOUNDS: A DIRECT PERIPHERAL AND CENTRAL COMPARISON
DP  - 1957 Mar 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 329--342
VI  - 119
IP  - 3
4099  - http://jpet.aspetjournals.org/content/119/3/329.short
4100  - http://jpet.aspetjournals.org/content/119/3/329.full
SO  - J Pharmacol Exp Ther1957 Mar 01; 119
AB  - A vascularly isolated, neurally intact head preparation has been used to determine whether succinylcholine, decamethonium or d-tubocurarine affect breathing by an action on central mechanisms. Doses of these compounds which produce a prolonged apnea in an anesthetized animal do not influence breathing in the absence of a peripheral effect. Thus, the data obtained in this study does not agree with the concept that these neuromuscular blocking compounds depress respiration by an action on central structures.