TY - JOUR T1 - SOME ASPECTS OF THE MECHANISM OF TOXICITY OF THIOGLYCOLATE JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 296 LP - 303 VL - 118 IS - 3 AU - M. V. Freeman AU - John H. Draize AU - Paul K. Smith Y1 - 1956/11/01 UR - http://jpet.aspetjournals.org/content/118/3/296.abstract N2 - Thioglycolic acid caused a marked hypoglycemia, a reduction in liver glycogen, an increase in respiratory quotients and an increase in urinary nitrogen excretion. Glucose by the oral or intraperitoneal route afforded approximately a fourfold protection against the lethal effects of thioglycolate. Cysteine and dimercaptopropanol did not cause a hypoglycemia in six hours as did thioglycolate. LD50 determinations showed that thioglycolate was more toxic to rats (male) than to mice (female) and was absorbed as rapidly from the gastrointestinal tract as from the peritoneal cavity. ER -