PT  - JOURNAL ARTICLE
AU  - F. M. BERGER
AU  - C. D. HENDLEY
AU  - B. J. LUDWIG
AU  - T. E. LYNES
TI  - CENTRAL DEPRESSANT AND ANTICONVULSANT ACTIVITY OF COMPOUNDS ISOMERIC WITH 2-METHYL-2-<em>n</em>-PROPYL-1 ,3-PROPANEDIOL DICARBAMATE (MILTOWN)
DP  - 1956 Mar 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 337--342
VI  - 116
IP  - 3
4099  - http://jpet.aspetjournals.org/content/116/3/337.short
4100  - http://jpet.aspetjournals.org/content/116/3/337.full
SO  - J Pharmacol Exp Ther1956 Mar 01; 116
AB  - Nine compounds isomeric with 2-methyl-2-n-propyl-1, 3-propanediol dicarbamate (Miltown) were tested in mice for their ability to produce paralysis, antagonize convulsions produced by pentylenetetrazole and modify maximal electroshock seizures. Miltown was the most potent compound in the series in paralyzing action and in preventing convulsions and death caused by pentylenetetrazole. The dicarbamates of 2-n-butyl-1, 3-propanediol and of 2-isobutyl-1, 3- propanediol were outstanding in their ability to modify maximal electroshock seizures. The relation between pharmacological action and physical properties is briefly discussed. The paralyzing potency and the ability of compounds to protect from pentylenetetrazole convulsions correlate well with the melting points but there was no significant correlation between the melting points and the ability of compounds to modify electroshock seizures. © 1956, by The Williams & Wilkins Company