TY - JOUR T1 - LOCAL ANESTHETIC AND PHARMACOLOGIC PROPERTIES OF 4n-BUTOXY β-(1-PIPERIDYL) PROPIOPHENONE HCl<sup>1</sup> AND β-DIETHYLAMINOETHYL p-n-HEXYLOXYBENZILATE HCl JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 413 LP - 418 VL - 115 IS - 4 AU - Ram B. Arora AU - Vishweshwar N. Sharma Y1 - 1955/12/01 UR - http://jpet.aspetjournals.org/content/115/4/413.abstract N2 - A pharmacologic comparison of a p-alkoxy substituted basic ester of benzilic acid and a p-alkoxy basic propiophenone has revealed the following: a. Both possess local anesthetic activity, the benzilic acid ester being more potent, but slower in onset of action and more irritant. b. Neither possesses cholinolytic nor cholinergic properties. c. Both depress arterial pressure partially by decreasing cardiac output and by "direct" vasodilatation. Studies in man with 4n-butoxy β-(1-piperidyl) propiophenone (dyclonine) indicate that it is a highly effective relatively non-irritating surface anesthetic agent, which can safely be employed in ophthalmic surgery. ER -