TY - JOUR T1 - THE PHARMACOLOGIC ACTIVITY OF α-(4-PIPERIDYL)-BENZHYDROL HYDROCHLORIDE (AZACYCLONOL HYDROCHLORIDE); AN ATARACTIVE AGENT JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 153 LP - 161 VL - 118 IS - 2 AU - Barbara B. Brown AU - Donald L. Braun AU - Robert G. Feldman Y1 - 1956/10/01 UR - http://jpet.aspetjournals.org/content/118/2/153.abstract N2 - The compound α-(4-piperidyl)-benzhydrol hydrochloride, azacyclonol, causes depressed activity in mice and rats when small to moderate doses are administered but causes stimulation in large doses. Cats and dogs respond to azacyclonol only by stimulation. Azacyclonol antagonizes increased coordination activity in mice induced by pipradrol, amphetamine, morphine and cocaine, and it antagonizes morphineinduced stimulation in cats. Hexobarbital hypnosis is prolonged by azacyclonol, and can be re-induced by azacyclonol after the mice are fully awake. The intravenous injections of azacyclonol in subjects with well-developed LSD-induced psychoses frequently caused prompt relief of the mental symptomatology. ER -