PT - JOURNAL ARTICLE AU - Weikel, John H. AU - Lusky, Lehman M. TI - PHARMACOLOGY OF THE RETICULO-ENDOTHELIAL SYSTEM. 1. BLOCKADE BY POLYVINYLPYRROLIDONE (PVP) AS MEASURED WITH RADIO-CHROMIC PHOSPHATE IN THE RABBIT DP - 1956 Oct 01 TA - Journal of Pharmacology and Experimental Therapeutics PG - 148--152 VI - 118 IP - 2 4099 - http://jpet.aspetjournals.org/content/118/2/148.short 4100 - http://jpet.aspetjournals.org/content/118/2/148.full SO - J Pharmacol Exp Ther1956 Oct 01; 118 AB - The correlation between polyvinylpyrrolidone storage in the reticulo-endothelial system and functional activity of that system has been examined using radioactive chromic phosphate. Polyvinylpyrrolidone was shown to depress the rate of phagocytosis of the colloid. It also caused a change in the distribution of the chromic phosphate among the organs of the reticuloendothelial system with more taken up by the lungs and less by the spleens of those animals treated with polyvinylpyrrolidone.