PT  - JOURNAL ARTICLE
AU  - Eugene D. Weinberg
AU  - Marilyn Shifter Foley
TI  - THE EFFECT OF METALLIC CATIONS ON THE ANTI-<em>STREPTOMYCES ACTIVITY</em> OF ANHYDROCHLORTETRACYCLINE
DP  - 1955 Sep 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 61--67
VI  - 115
IP  - 1
4099  - http://jpet.aspetjournals.org/content/115/1/61.short
4100  - http://jpet.aspetjournals.org/content/115/1/61.full
SO  - J Pharmacol Exp Ther1955 Sep 01; 115
AB  - The ability of 25 multivalent ions to suppress the toxicity of anhydrochlor-tetracycline towards three species of Streptomyces was studied. Of the ions, only Fe++ was active. The results of similar studies with oxy-, chlor-, and tetracycline in which one algal and ten bacterial species were employed are briefly reviewed. With each strain either Fe++ or Mg++ or both were the strongest drug-reversing ions. The active ions varied with the microbial species and with the type of medium employed but not with the kind of tetracycline compound.