PT  - JOURNAL ARTICLE
AU  - Greco, F. Del
AU  - Corcoran, A. C.
AU  - Page, Irvine H.
TI  - HYPOSTHENURIA AND OTHER RENAL EFFECTS OF HEXAMETHONIUM IN THE HYDROPENIC ANESTHETIZED DOG
DP  - 1956 Aug 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 434--442
VI  - 117
IP  - 4
4099  - http://jpet.aspetjournals.org/content/117/4/434.short
4100  - http://jpet.aspetjournals.org/content/117/4/434.full
SO  - J Pharmacol Exp Ther1956 Aug 01; 117
AB  - Effects of hexamethonium on renal functions were examined in eleven experiments in hydropenic, anesthetized dogs in osmotic diuresis. In most experiments, the depressor effect of hexamethonium on arterial pressure was associated with decreases in calculated renal vascular resistance, and variable, small changes in plasma clearance of PAH. Clearance of mannitol was also variably affected, with considerable decreases in 4 and no changes or slight decreases in seven. Dilution of the urine (hyposthenuria) occurred in 10 of 11 experiments, in 7 of which it was associated with increases in rates of urine flow, and in 4 with increased outputs of sodium and chloride. The effects of hexamethonium blockade on water and electrolyte outputs point to the existence of neural influences on renal tubular reabsorptive functions. These may act either at the cellular level or, as logical economy suggests, they may affect reabsorption by altering distribution of blood flow around renal tubules.