RT Journal Article
SR Electronic
T1 THE PARMACOLOGY OF β-AMINOETHYLISOTHIURONIUM BROMIDE IN THE CAT
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 425
OP 433
VO 117
IS 4
A1 DiStefano, Victor
A1 Leary, Daniel E.
A1 Doherty, David G.
YR 1956
UL http://jpet.aspetjournals.org/content/117/4/425.abstract
AB Low doses of AET (2.5 mgm./kgm.) evoke a fall in blood pressure, bradycardia and apnea; this triad may be abolished by section of the vagi. Atropine blocks the bradycardia and hypotension but not the apnea. Gut contractions which may be abolished by atropine are also noted. Larger doses of AET sometimes produce a biphasic blood pressure response, a fall followed by a rise. The nature of the hypertensive mechanism is obscure. Inhibition of nictitating membrane contractions with doses of AET above 10 mgm./kgm. is mediated both by alterations in ganglionic transmission and a direct effect on the nictitating membrane. A slight augmentation of skeletal muscle contractions is noted with larger doses of AET (15 to 20 mgm./kgm.). Convulsions and death follow doses in excess of 25 mgm./kgm.