PT  - JOURNAL ARTICLE
AU  - DiStefano, Victor
AU  - Leary, Daniel E.
AU  - Doherty, David G.
TI  - THE PARMACOLOGY OF β-AMINOETHYLISOTHIURONIUM BROMIDE IN THE CAT
DP  - 1956 Aug 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 425--433
VI  - 117
IP  - 4
4099  - http://jpet.aspetjournals.org/content/117/4/425.short
4100  - http://jpet.aspetjournals.org/content/117/4/425.full
SO  - J Pharmacol Exp Ther1956 Aug 01; 117
AB  - Low doses of AET (2.5 mgm./kgm.) evoke a fall in blood pressure, bradycardia and apnea; this triad may be abolished by section of the vagi. Atropine blocks the bradycardia and hypotension but not the apnea. Gut contractions which may be abolished by atropine are also noted. Larger doses of AET sometimes produce a biphasic blood pressure response, a fall followed by a rise. The nature of the hypertensive mechanism is obscure. Inhibition of nictitating membrane contractions with doses of AET above 10 mgm./kgm. is mediated both by alterations in ganglionic transmission and a direct effect on the nictitating membrane. A slight augmentation of skeletal muscle contractions is noted with larger doses of AET (15 to 20 mgm./kgm.). Convulsions and death follow doses in excess of 25 mgm./kgm.